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Recently Published Manuscripts by ImQuest BioSciences Staff
- Chen, X., Yang, L., Zhang, N., Turpin, J.A., Buckheit, R.W., Osterling, C., Oppenheim, J.J. and Howard, O.M.Z. Shikonin, a component of Chinese herbal medicine, inhibits chemokine receptor function and suppresses human immunodeficiency virus type-1. Antimicrob. Agents Chemother. 47: 2810-2816. 2003.
- Novikov, M.S., Ozerov, A.A., Sim, O.G. and Buckheit, R.W., Jr. Synthesis and anti-HIV-1 activity of 2-[[2-(3,5-dimethylphenoxy)ethyl]thio]pyrimidin-4(3H)-ones. Chemistry of Heterocyclic Compounds. 40:37-42. 2004.
- Buckheit, R.W., Jr. Understanding HIV resistance, fitness, replication capacity and compensation: targeting viral fitness as a therapeutic strategy. In press. Expert Opin. Investig. Drugs 13: 933-958. 2004.
- .Ozerov A.A., Novikov M.S., Gnatjuk V.P., Lobachev A.A., Buckheit R.W. Synthesis and anti-HIV-1 activity of 1-(benzyloxymethyl)-5-(arylamino)uracil derivatives methylated in side chain. Bulletin of Volgograd Scientific Centre of Russian Academy of Medical Sciences.1:26-28. 2004.
- Novikov M.S., Sim O.G., Ozerov A.A., Buckheit R.W. Synthesis and antiviral activity of 2-(alkylthio)-5-[2-(aryloxy)ethyl]-6-methylpyrimidine-4(3H)-ones. Bulletin of Volgograd Scientific Centre of Russian Academy of Medical Sciences. 2:30-31. 2004.
- Colleluori, D.M., Tien, D., Kang, F., Pagliei, T., Kuss, R., McCormick, T., Watson, K., McFadden, K., Chaiken, I., Buckheit, R.W., Jr. and Romano, J.W. Expression, purification, and characterization of recombinant cyanovirin-N for vaginal anti-HIV microbicide development. Protein Expression and Purification. 39:229-236. 2004.
- Mori, T., O’Keefe, B.R., Sowder III, R.C., Bringans, S., Gardella, R., Berg, S., Cochran, P., Turpin, J.A., Buckheit, R.W., Jr., McMahon, J.B. and Boyd, M.R. Isolation and characterization of griffithsin, a novel HIV-inactivating protein from the red algae Griffithsia sp. J. Biol. Chemistry. 280:9345-9353. 2005.
- Horvath, A., Tokes, S., Hartman, T., Watson, K., Turpin, J.A., Buckheit, R.W., Jr., Sebesteyen, Z., Szollosi, J., Benko, I., Bardos, T.J., Dunn, J.A., Toth, F.D., Fesus, L. and Aradi, J. Suligovir [(s4dU)35] inhibits HIV-1 entry by targeting CD4 and cell surface thioredoxin. Virology. 334:214-223. 2005.
- Novikov, M.S., Ozerov, A.A., Orlova, J.A., Buckheit, R.W., Jr. Synthesis and antiviral properties of 1-{[2-(phenoxy)ethoxy]methyl}uracil derivatives. Chemistry of Heterocyclic Compounds. 5:726-731. 2005.
- Tien, D., Schnaare, R.L., Cohl, G., Moench, T., Doncel, G., Watson, K., Buckheit, R.W., Jr., Lewis, M., Mauck, C., Callahan, M., Douville, K. and Romano, J.W. In vitro and in vivo characterization of a potential universal placebo designed for use in vaginal microbicide clinical trials. AIDS Res. Hu. Retrov. 21: 11-19. 2005..
- Beer, B.E., Doncel, G.F., Krebs, F.C., Shattock, R., Fletcher, P., Buckheit, R.W., Jr., Watson, K., Dezzutti, C.S., Cummins, J.E., Bromley, E., Richardson-Harman, N., Pallansch, L., Lackman-Smith, C., Ostreling, C., Mankowski, M., Miller, S.R., Catalone, B.J., Welsh, P.A., Howett, M.K., Wigdahl, B., Turpin, J.A. and Reichelderfer, P. In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories. Antimicrob. Agents Chemother. 50:713-723. 2006.
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Works in Progress Involving ImQuest BioSciences Staff
- Deng, B.L., Cullen, M.D., Zhou, Z., Hartman, T.L., Buckheit, R.W., Jr., Pannecouque, C., DeClercq, E., Fanwick, P.E. and Cushman, M. Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings. In press. 2005.
- Srivastava, P., Hara, T., Fattah, R.J., Schito, M., Hartman, T., Buckheit, R.W., Jr., Turpin, J.A., Inman, J.K., and Appella, E. Optimization of unique thioesters as antiviral agents that target HIV-1 nucleocapsid protein (NCp7). Submitted. 2005.
- Schito, M.L., Hartman, T., Soloff, A.C., Fattah, R.J., Slovitz, D., Trichel, A., Inman, J., Buckheit, R.W., Jr., Appella, E. and Barratt-Boyes, S.M. Zinc finger inhibitor targeting human immunodeficiency virus nucleocapsid is virucidal in the nonhuman primate model. Submitted. 2005.
- José A. Fernández-Romero, Mitchell Thorn, Kanani Titchen, Kristin Sudol, Jifan Li, Robin A Maguire, Robert W. Buckheit Jr, Tracy L. Hartman, David M Phillips Carrageenan/MIV-150 (PC-815), a combination microbicide. Submitted. 2005.
- Turpin, J.A., Loftus, T.L., Watson, K., Kwon, H-S., Lee, S-H., Lee, J-W., Kang, D-W., Chung, S-G., Cho, E-H., and Buckheit, R.W., Jr. The structure-activity relationships of 2,4 (1H, 3H)-pyrimidinedione derivatives as potent human immunodeficiency virus inhibitors. To be submitted.
- Buckheit, R.W., Jr., Palmer, S., Fliakas-Boltz, V., Russell, J., Hartman, T.L., Watson, K., Chung, S-G and Cho, E-H. SJ-3366 rapidly selects for resistant strains of HIV-1 and HIV-2 with reduced sensitivity to virus entry and reverse transcriptase inhibition. To be submitted.
- Buckheit, R.W., Jr., Watson, K., Hartman, T.L., Chung, S-G., Cho, E-H, and Turpin, J.A. SJ-3366 inhibits virus entry through interaction with a post-attachment intermediate. To be submitted.
- Hartman, T.L., Turpin, J.A. and Buckheit, R.W., Jr. Effect of NNRTI-resistance engendering mutations on viral fitness. To be submitted.
- Buckheit, R.W., Jr. Considerations in the Development of Anti-HIV Therapeutics and Microbicides: Preclinical Drug Development Challenges. Commissioned by Expert Opin. Investig. Drugs 2006.
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